Hormonal
Dietary interventions, specifically intermittent fasting (IF) and caloric restriction (CR), improve metabolic profiles (body weight, glucose homeostasis, insulin sensitivity) by inducing epigenetic modifications (DNA methylation and histone modification) in metabolic tissues like adipose, liver, and pancreas.
To improve metabolic health, consider adopting time-restricted feeding (e.g., eating within an 8-10 hour window) or intermittent fasting protocols (like 5:2 or 2:1). These methods can improve insulin sensitivity and reduce body weight, potentially through beneficial changes in how your genes are expressed in fat and liver tissue. Start with a manageable window and consult a healthcare provider, especially if you have diabetes.
Dietary interventions, including caloric restriction, intermittent fasting or time-restricted feeding, have shown promising improvements in patients’ overall metabolic profiles (i.e., reduced body weight, improved glucose homeostasis), and an increasing number of studies have associated these beneficial effects with epigenetic alterations.
Why this rating
This is a review paper summarizing multiple animal and human studies; it does not present new primary data but synthesizes existing evidence.
Source
Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases
Shaza Asif et al. · Frontiers in Genetics · 2020
DOI 10.3389/fgene.2020.590369
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