Macro partitioning
Natural compounds, specifically oligomeric procyanidins from apple polyphenol extract and tetrahydrofuran from nutmeg, inhibit pancreatic lipase activity in vitro and in animal models, potentially offering safer alternatives to synthetic inhibitors.
Some natural extracts, like those from apples (procyanidins) and nutmeg, show promise in blocking fat-digesting enzymes in lab tests. However, they are not yet proven to be effective or safe for weight loss in humans compared to established treatments. Do not rely on them as a primary weight loss strategy without medical guidance.
The study found that the inhibitory power of pancreatic lipase is closely related to the degree of polymerization, with oligomeric procyanidin being a key contributor... nutmeg strongly inhibited PL activity by 66.24%
Why this rating
Based on in vitro and animal studies cited in a review; human clinical efficacy data is not detailed in the text.
Source
Role of pancreatic lipase inhibition in obesity treatment: mechanisms and challenges towards current insights and future directions
Vetriselvan Subramaniyan et al. · International Journal of Obesity · 2025
DOI 10.1038/s41366-025-01729-1
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