Hormonal
Administration of the ketone metabolite BHB-Phe (N-beta-hydroxybutyryl phenylalanine) suppresses food intake and reduces body weight in obese mice.
This research identifies a specific metabolite, BHB-Phe, which is naturally produced during ketosis and actively suppresses hunger. While the study used high-dose injections in obese mice, it suggests that maintaining ketosis may naturally elevate this compound, contributing to reduced food intake. For now, this is a mechanistic insight rather than a direct supplement recommendation, as oral bioavailability and dosing in humans are not established.
N-beta-hydroxybutyryl phenylalanine (BHB-Phe), the most abundant BHB-amino acid, is a structural and functional congener of Lac-Phe that suppresses feeding upon administration to obese mice.
Why this rating
Strong experimental evidence in murine models with clear dose-response and genetic validation (CNDP2-KO), though human data is limited to metabolite detection.
Source
A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites
María Dolores Moya-Garzón et al. · Cell · 2024
DOI 10.1016/j.cell.2024.10.032
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