Research
Hormonal
Prolonged fasting is associated with a significant decrease in glucose tolerance after a normal mixed meal.
Practitioners should be aware that prolonged fasting may impair glucose tolerance, impacting meal planning.
StrongSupportsmedium confidence
With 72 h of fasting, the glucose and insulin excursions in response to the mixed meal were significantly greater compared with the 13-h fast (P < 0.001).
Why this rating
Based on study design from abstract.
Source
Prolonged fasting significantly changes nutrient oxidation and glucose tolerance after a normal mixed meal
Tracy J. Horton et al. · Journal of Applied Physiology · 2001
DOI 10.1152/jappl.2001.90.1.155
other · n=8Cited 56×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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