Hormonal
Exenatide (GLP-1 RA) reduces parasympathetic nervous system activity, which may contribute to an increase in heart rate, but does not significantly lower systolic blood pressure on its own in this population.
Exenatide alone may not significantly lower blood pressure in people with type 2 diabetes and obesity, but it does reduce parasympathetic nervous system activity, which can increase heart rate. It is often used in combination with other drugs for better cardiovascular outcomes.
Exenatide had no effect on SBP, but reduced parasympathetic nervous system activity after 10 days and 16 weeks.
Why this rating
RCT design, but small sample size.
Source
Mechanisms underlying the blood pressure lowering effects of dapagliflozin, exenatide, and their combination in people with type 2 diabetes: a secondary analysis of a randomized trial
Charlotte C. van Ruiten et al. · Cardiovascular Diabetology · 2022
DOI 10.1186/s12933-022-01492-x
More from this paper
- Dapagliflozin (SGLT2 inhibitor) lowers systolic blood pressure through an initial plasma volume contraction followed by a sustained reduction in sympathetic nervous system activity.Good
- Combining Dapagliflozin and Exenatide results in a synergistic blood pressure reduction that exceeds the sum of their individual effects, driven by plasma volume contraction and potentially other mechanisms beyond SNS reduction.Good
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