Research
Hormonal
Tirzepatide, a dual GIP/GLP-1 receptor agonist, significantly reduces systolic and diastolic blood pressure in patients with type 2 diabetes and obesity.
If you have type 2 diabetes or obesity, tirzepatide (a once-weekly injection) can help lower your blood pressure, which reduces your overall cardiovascular risk. The blood pressure reduction is dose-dependent, meaning higher doses tend to lower BP more.
GoodSupportsHIGH confidence
Tirzepatide has also been shown to reduce BP in clinical studies. The patients treated with tirzepatide showed significantly lowered systolic and diastolic BP compared with patients in the control group, regardless of whether tirzepatide was used as a monotherapy or add-on therapy. Overall, tirzepatide treatment reduced systolic and diastolic BP by 4.8 and 1.7 mmHg, respectively.
Why this rating
Based on multiple phase 3 clinical trials (SURPASS programs) and a dedicated ABPM sub-study.
Source
The Cardiovascular Effect of Tirzepatide: A Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide Dual Agonist
Yun Kyung Cho et al. · Journal of Lipid and Atherosclerosis · 2023
DOI 10.12997/jla.2023.12.3.213
narrative_reviewCited 52×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide significantly reduces body weight and improves lipid profiles (lowering LDL-C and triglycerides, raising HDL-C) in patients with T2DM and obesity.Strong
- Tirzepatide reduces inflammatory markers associated with cardiovascular risk, including YKL-40, ICAM-1, leptin, and GDF-15.Good
- Tirzepatide does not increase the risk of major adverse cardiovascular events (MACEs) in patients with type 2 diabetes.Good
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