Research
Hormonal
GLP-1 RAs are not associated with progression to proliferative diabetic retinopathy (HR, 1.06; 95% CI, 0.97-1.15) or diabetic macular edema (HR, 0.98; 95% CI, 0.95-1.01) in patients with preexisting DR.
Patients with preexisting DR may not experience worsening of certain complications when treated with GLP-1 RAs.
StrongRefutesmedium confidence
GLP-1 RAs were not associated with progression to proliferative DR (HR, 1.06; 95% CI, 0.97-1.15) or diabetic macular edema (HR, 0.98; 95% CI, 0.95-1.01).
Why this rating
Based on a large retrospective cohort study design.
Source
GLP-1 Receptor Agonists and Sight-Threatening Ophthalmic Complications in Patients With Type 2 Diabetes
David J. Ramsey et al. · JAMA Network Open · 2025
DOI 10.1001/jamanetworkopen.2025.26321
cohort · n=185066Cited 41×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Use of GLP-1 receptor agonists (GLP-1 RAs) is associated with an increased incidence of diabetic retinopathy (DR) with a hazard ratio (HR) of 1.07 (95% CI, 1.03-1.11).Strong
- Patients treated with GLP-1 RAs experienced a lower occurrence of sight-threatening complications, including blindness (HR, 0.77; 95% CI, 0.73-0.82).Strong
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