Research
Hormonal
Excess body weight is a significant risk factor for breast cancer and increases the risk of therapy-related morbidity, recurrence, and breast cancer-related mortality.
Healthcare providers should prioritize weight management in breast cancer patients and survivors.
StrongSupportsmedium confidence
Excess body weight is a significant risk factor for many cancers, especially breast cancer.
Why this rating
The claims are based on established cancer risk factors.
Source
Obese Breast Cancer Patients and Survivors: Management Considerations.
Jennifer Y. Sheng et al. · PubMed · 2018
reviewCited 41×
Read the paper More from this paper
- Obesity affects quality-of-life factors for breast cancer survivors, including sexual dysfunction, neuropathy, cardiotoxicity, chronic fatigue, and lymphedema.Strong
- Cancer guidelines recommend that overweight or obese breast cancer survivors lose weight and that those with a normal BMI maintain stable body weight.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →