Research
Hormonal
Short-acting GLP-1 receptor agonists are associated with an increased risk of erosive reflux disease (ERD) with a hazard ratio (HR) of 1.215.
Clinicians should be cautious when prescribing short-acting GLP-1 RAs to patients with type 2 diabetes due to the increased risk of ERD.
StrongSupportsmedium confidence
GLP-1 RA exposure was associated with an increased risk (HR 1.15; 95% CI 1.09 to 1.22) of erosive reflux disease (ERD). However, this was solely due to short-acting (HR 1.215; 95% CI 1.111 to 1.328).
Why this rating
Based on a large cohort study design.
Source
Shorter-acting glucagon-like peptide-1 receptor agonists are associated with increased development of gastro-oesophageal reflux disease and its complications in patients with type 2 diabetes mellitus: a population-level retrospective matched cohort study
Benjamin D. Liu et al. · Gut · 2023
DOI 10.1136/gutjnl-2023-329651
cohort · n=1543351Cited 38×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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