Research
Hormonal
Baseline muscle protein synthesis (MPS) during androgen deprivation therapy (ADT) is suppressed relative to age-matched controls.
Practitioners should be aware that ADT may lead to reduced muscle protein synthesis in patients.
StrongSupportsmedium confidence
Baseline MPS during ADT was suppressed relative to CON (P = 0.01).
Why this rating
Based on the comparison of MPS between groups in a controlled setting.
Source
Attenuation of Resting but Not Load-Mediated Protein Synthesis in Prostate Cancer Patients on Androgen Deprivation
Erik D. Hanson et al. · The Journal of Clinical Endocrinology & Metabolism · 2017
DOI 10.1210/jc.2016-3383
other · n=18Cited 34×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →