Research
Hormonal
GLP-1 receptor agonists (e.g., liraglutide) produce significant weight loss (mean 8.4 kg over 56 weeks) by slowing gastric emptying and activating central satiety pathways, with 33.1% of patients achieving >10% body weight loss.
If you have obesity (BMI > 30, or > 27 with health issues), ask your doctor about GLP-1 agonists like liraglutide. This medication, taken daily, has been shown in clinical trials to help patients lose an average of 8.4 kg over a year, with many losing over 10% of their body weight. It works by slowing digestion and signaling fullness to your brain.
GoodSupportsHIGH confidence
A multicenter RCT evaluating daily 3 mg liraglutide administration in overweight/obese participants (BMI > 27 kg/m2 with comorbidities or > 30 kg/m2) reported 8.4 kg mean weight reduction over 56 weeks, with 33.1% achieving > 10% body weight loss [74].
Why this rating
Cites a multicenter RCT, which is high-quality evidence, though it is a review paper summarizing it.
Source
Obesity: pathophysiology and therapeutic interventions
Yue Kong et al. · Molecular Biomedicine · 2025
DOI 10.1186/s43556-025-00264-9
narrative_reviewCited 44×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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