Research
Hormonal
GIP is overexpressed in obese individuals, which may exacerbate insulin resistance.
Addressing GIP levels may be important in treating obesity-related insulin resistance.
StrongSupportsmedium confidence
GIP is overexpressed in obese individuals, which may exacerbate insulin resistance manifested by many patients with type 2 diabetes mellitus.
Why this rating
The claim is supported by physiological observations.
Source
Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease
M. Michael Wolfe et al. · Endocrine Reviews · 2025
DOI 10.1210/endrev/bnaf006
reviewCited 24×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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