Hormonal
Tirzepatide treatment in patients with obesity and type 1 diabetes results in significant weight loss (median 8.5-12.2%) and reduced insulin requirements without increasing hypoglycemia or serious adverse events.
If you have Type 1 Diabetes and obesity, Tirzepatide is a viable option for weight loss and reducing insulin needs. Start with a low dose (2.5mg) and increase slowly to minimize nausea. You must work with your doctor to adjust your insulin doses to prevent hypoglycemia. Combine the medication with a modest calorie deficit and regular exercise for best results.
A retrospective study at Mayo Clinic found that tirzepatide use in adults with type 1 diabetes and obesity resulted in a median weight loss of 8.5% (12.2% at 12 months), a 0.9% reduction in HbA1c, and a 31.6% decrease in daily insulin requirements, with no increase in hypoglycaemia or serious adverse events.
Why this rating
Based on retrospective observational data and a short-term pilot study (TIRTLE1), not yet the full long-term RCT results.
Source
Treatment of the disease of obesity in patients with type 1 diabetes with tirzepatide: a protocol for a randomised controlled trial in a single-centre setting
Ebaa Al Ozairi et al. · BMJ Open · 2026
DOI 10.1136/bmjopen-2026-117431
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