Research
Hormonal
The appetite-suppressing effects of GLP-1 analogs attenuate during the weight maintenance phase, suggesting that the biological drive to lose weight diminishes once a new homeostatic fat mass is reached.
As you reach your target weight, the strong appetite suppression from GLP-1 medications may lessen. This is a normal physiological response as your body adjusts to its new weight. Continued monitoring and potentially lifestyle adjustments may be needed to maintain weight loss.
ModerateQualifiesMEDIUM confidence
The initial changes seen during the weight loss phase were attenuated during the weight-loss maintenance phase [42], suggesting that once the patients achieve a new homeostatic fat mass, the biological drive to lose weight diminishes.
Why this rating
Based on a 104-week study using verbal reports; objective data is sparse.
Source
Changes in food preferences and ingestive behaviors after glucagon-like peptide-1 analog treatment: techniques and opportunities
Sahana Bettadapura et al. · International Journal of Obesity · 2024
DOI 10.1038/s41366-024-01500-y
narrative_reviewCited 41×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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