Research
Hormonal
Naltrexone/bupropion increased proglucagon levels and decreased GLP-2, glucagon, and the major proglucagon fragment.
Naltrexone/bupropion may be beneficial for altering specific hormone levels related to metabolism.
StrongSupportsmedium confidence
Naltrexone/bupropion produced a weight-independent increase in the levels of proglucagon (P < .001) and decreases in glucagon-like peptide-2 (GLP-2), glucagon and the major proglucagon fragment (P ≤ .01).
Why this rating
Based on the interventional study design with statistical significance reported.
Source
Circulating levels of proglucagon‐derived peptides are differentially regulated by the glucagon‐like peptide‐1 agonist liraglutide and the centrally acting naltrexone/bupropion and can predict future weight loss and metabolic improvements: A 6‐month long interventional study
Konstantinos Stefanakis et al. · Diabetes Obesity and Metabolism · 2023
DOI 10.1111/dom.15141
rct · n=17Cited 15×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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