Hormonal
Subcutaneous Tirzepatide significantly reduces body weight, BMI, and waist circumference in adults with obesity or type 2 diabetes compared to placebo.
If you have obesity or type 2 diabetes and lifestyle changes haven't been enough, Tirzepatide is a highly effective, once-weekly injection that significantly reduces weight, BMI, and waist circumference. The effect is dose-dependent, with higher doses (up to 15mg) yielding greater weight loss. Be prepared for potential gastrointestinal side effects like nausea, which are common but often manageable.
The pooled findings showed that Tirzepatide vs placebo significantly reduced body weight (weighted mean difference (WMD): -11.34 kg, 95% confidence interval (CI): -12.79 to -9.88, P< 0.001), body mass index (BMI) (WMD: -3.11 kg/m2, 95% CI: -4.36 to -1.86, P< 0.001), and waist circumference (WC) (WMD: -7.24 cm 95% CI -10.12 to -4.36, P< 0.001).
Why this rating
High-quality systematic review and meta-analysis of 8 RCTs with 7062 participants, though heterogeneity was high.
Source
The effects of subcutaneous Tirzepatide on obesity and overweight: a systematic review and meta‐regression analysis of randomized controlled trials
Pejman Rohani et al. · Frontiers in Endocrinology · 2023
DOI 10.3389/fendo.2023.1230206
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