Research
Macro partitioning
Lipase inhibitors (orlistat and cetilistat) reduce weight by inhibiting fat absorption, but are associated with gastrointestinal side effects and are less effective in patients with diabetes.
Orlistat is a daily pill that blocks fat absorption. It is taken with meals containing fat. It can cause gastrointestinal side effects like oily stools. It is not effective for patients with diabetes.
GoodSupportsHIGH confidence
Orlistat acts by reversibly inhibiting lipases by covalently binding to serine residues of active sites and inactivating them, thereby blocking fat hydrolysis and decreasing fat absorption... Although orlistat is effective in prediabetic patients, it lacks a role in decreasing obesity in patients diagnosed with DM.
Why this rating
Based on FDA approval and clinical studies.
Source
Advances in Anti-obesity Pharmacotherapy: Current Treatments, Emerging Therapies, and Challenges
Skyler Brandfon et al. · Cureus · 2023
DOI 10.7759/cureus.46623
narrative_reviewCited 38×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- GLP-1 receptor agonists (semaglutide 2.4 mg/week and liraglutide 3 mg/day) produce significant weight loss in adults with obesity or overweight with comorbidities by delaying gastric emptying and increasing satiety, with semaglutide demonstrating superior efficacy compared to liraglutide.Good
- Leptin analogs (metreleptin) are effective for treating obesity only in patients with generalized lipodystrophy or congenital leptin deficiency, but are ineffective and contraindicated for general diet-based obesity due to leptin resistance.Good
- MC4R agonists (setmelanotide) are effective for treating obesity in individuals with specific genetic deficiencies (POMC, PCSK1, LEPR) or Bardet-Biedl syndrome, but are not approved for general obesity.Good
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →