Research
Macro partitioning
Lipase inhibitors (orlistat and cetilistat) reduce weight by inhibiting fat absorption, but are associated with gastrointestinal side effects and are less effective in patients with diabetes.
Orlistat is a daily pill that blocks fat absorption. It is taken with meals containing fat. It can cause gastrointestinal side effects like oily stools. It is not effective for patients with diabetes.
GoodSupportsHIGH confidence
Orlistat acts by reversibly inhibiting lipases by covalently binding to serine residues of active sites and inactivating them, thereby blocking fat hydrolysis and decreasing fat absorption... Although orlistat is effective in prediabetic patients, it lacks a role in decreasing obesity in patients diagnosed with DM.
Why this rating
Based on FDA approval and clinical studies.
Source
Advances in Anti-obesity Pharmacotherapy: Current Treatments, Emerging Therapies, and Challenges
Skyler Brandfon et al. · Cureus · 2023
narrative_reviewCited 38×
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