Hormonal
Intentional weight loss in older adults using anti-obesity medicines (AOMs) improves cardiometabolic outcomes and preserves skeletal muscle strength and bone mineral density, countering the risks of sarcopenia and functional decline.
If you are over 60 and have obesity, intentional weight loss using FDA-approved medications (like semaglutide or tirzepatide) combined with resistance training is safe and effective. It improves heart and metabolic health without necessarily causing frailty, provided you work with a clinician to manage side effects and maintain muscle mass.
Intentional weight loss in older adults improves cardiometabolic outcomes and is more likely to preserve skeletal muscle strength and bone mineral density
Why this rating
Based on a narrative review of multiple RCTs (SCALE, STEP, SURMOUNT) and meta-analyses, though direct large-scale trials in >60s are limited.
Source
Obesity pharmacotherapy in older adults: a narrative review of evidence
Alex E. Henney et al. · International Journal of Obesity · 2024
DOI 10.1038/s41366-024-01529-z
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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