Research
Hormonal
GLP-1/GIP receptor co-agonists may provide cardiovascular protection and slow the decline of kidney function in individuals with type 2 diabetes.
GLP-1/GIP receptor co-agonists may be considered for patients with type 2 diabetes at risk for cardiovascular and kidney issues.
GoodQualifiesmedium confidence
A post hoc analysis suggested tirzepatide slows the decline of kidney function in T2D.
Why this rating
Based on post hoc analysis of clinical data.
Source
Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptor co-agonists for cardioprotection, type 2 diabetes and obesity: a review of mechanisms and clinical data
Ronald Goldenberg et al. · Current Opinion in Cardiology · 2023
DOI 10.1097/hco.0000000000001084
reviewCited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide, a GLP-1/GIP receptor co-agonist, is approved for type 2 diabetes and shows significant reductions in glycemia and body weight compared to GLP-1R mono-agonism with semaglutide.Strong
- Tirzepatide has demonstrated significant body weight reductions in individuals with obesity but not diabetes.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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