Adherence
A personalized low-glycemic index (Low-GI) diet informed by nutrigenetic testing yields superior long-term weight loss and cardiometabolic improvements compared to a standard ketogenic diet, primarily through enhanced dietary adherence rather than immediate metabolic advantage.
If you are struggling to keep weight off after losing it, consider that 'one-size-fits-all' diets like Keto may not be sustainable for you long-term. A personalized approach that adjusts your carbohydrate and fat intake based on your genetic profile (specifically genes related to metabolism and sensitivity) can help you maintain weight loss and improve cholesterol and blood sugar levels. This works best when the diet is tailored to your biology, making it easier to stick to over the long haul.
These findings demonstrate that the ketogenic group experienced enhanced weight loss during the 24-week dietary intervention. However, at 18-month follow up, the personalised nutrition group (lowGI/NG) lost significantly more weight and experienced significantly greater improvements in measures of cholesterol and blood glucose. This suggests that personalising nutrition has the potential to enhance long-term weight loss and changes in cardiometabolic parameters.
Why this rating
The study is a randomized controlled trial with a large sample size (n=114) and a long follow-up (18 months), but it lacks blinding, has a self-selected design (subjects chose their diet), and uses a non-standard control (ketogenic) rather than a standard healthy diet.
Source
A comparison of a ketogenic diet with a LowGI/nutrigenetic diet over 6 months for weight loss and 18-month follow-up
Maria Vrânceanu et al. · BMC Nutrition · 2020
DOI 10.1186/s40795-020-00370-7
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