Research
Hormonal
GLP-1RAs probably have little or no effect on risk for thyroid cancer.
Practitioners should consider that GLP-1RAs may not significantly increase thyroid cancer risk based on current evidence.
StrongQualifiesmedium confidence
GLP-1RAs probably have little or no effect on risk for thyroid cancer (OR, 1.37 [95% CI, 0.82 to 2.31]; 1 fewer to 9 more cases per 10 000 patients treated).
Why this rating
Based on a meta-analysis of randomized placebo-controlled trials.
Source
Risk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists
Albert Ko et al. · Annals of Internal Medicine · 2025
DOI 10.7326/annals-25-02237
Meta-analysisCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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