Macro partitioning
Replacing saturated fatty acids with polyunsaturated fatty acids (PUFA) or monounsaturated fatty acids (MUFA) decreases total LDL cholesterol but may increase small, dense LDL particles or have no effect on LDL particle size.
Replacing saturated fats with unsaturated fats (like olive oil or nuts) lowers total LDL cholesterol, which is generally beneficial. However, this shift may also increase small, dense LDL particles in some individuals, which are more strongly linked to heart disease. The net effect on cardiovascular risk is complex and depends on the overall dietary pattern.
replacing a portion of saturated fat with polyunsaturated fat decreased CHD events... However, certain studies are not in agreement with this recommendation, as saturated fatty acid intake did not increase the risk for CVD, cardiovascular events, and/or mortality.
Why this rating
Based on narrative review of multiple RCTs showing consistent LDL-C reduction but variable particle size effects.
Source
The effects of fat consumption on low-density lipoprotein particle size in healthy individuals: a narrative review
Erik Froyen · Lipids in Health and Disease · 2021
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