Hormonal
An acute high-fat diet increases the activity of AMPK and SIRT1 in skeletal muscle (via phosphorylation and deacetylation, respectively) without changing the total protein or mRNA levels of these enzymes.
Your body can rapidly switch on fat-burning enzymes in your muscles just by changing what you eat, even if the total amount of those enzymes doesn't change. This happens through chemical tags (phosphorylation/deacetylation) that activate the enzymes. This is a fast-acting regulatory mechanism, not a slow structural change.
the amount of de-acetylated PGC1-a and pAMPK were increased in both LN and OB indicating an increase in the activity of both SIRT1 and AMPK respectively.
Why this rating
Direct measurement of protein modifications via immunoblotting in muscle biopsies.
Source
Increasing Dietary Fat Elicits Similar Changes in Fat Oxidation and Markers of Muscle Oxidative Capacity in Lean and Obese Humans
Audrey Bergouignan et al. · PLoS ONE · 2012
DOI 10.1371/journal.pone.0030164
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