Research
Hormonal
Effects on gastric emptying appeared additive when BI 1820237 was combined with low-dose liraglutide.
Combining BI 1820237 with liraglutide may enhance effects on gastric emptying, which could be relevant for treatment strategies.
StrongSupportsmedium confidence
Post-dose paracetamol PK suggested that BI 1820237 and low-dose liraglutide exhibited additive effects on gastric emptying.
Why this rating
Based on the randomized phase I study design.
Source
A randomized phase I study of <scp>BI</scp> 1820237, a novel neuropeptide Y receptor type 2 agonist, alone or in combination with low‐dose liraglutide in otherwise healthy men with overweight or obesity
Nadine Beetz et al. · Diabetes Obesity and Metabolism · 2024
rct · n=74Cited 8×
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