Hormonal
Exogenous oxytocin administration reduces body weight and food intake in diet-induced obese rodents and non-human primates by acting on oxytocin receptors in the hindbrain (NTS) and hypothalamus to enhance satiety signals and increase energy expenditure.
Research suggests oxytocin may help reduce food intake and increase energy expenditure in obese individuals, particularly those with leptin resistance. However, current human trials are short-term, and long-term safety and optimal dosing (especially via intranasal spray) are still being determined. It is not yet a standard, widely available treatment for obesity.
We and others have shown that OT circumvents leptin resistance and elicits weight loss in diet-induced obese rodents and non-human primates by reducing both food intake and increasing energy expenditure (EE).
Why this rating
Strong evidence in rodents and primates, but human evidence is limited to short-term trials with small sample sizes and potential side effects.
Source
Oxytocin as an Anti-obesity Treatment
Jingjing Niu et al. · Frontiers in Neuroscience · 2021
DOI 10.3389/fnins.2021.743546
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →