Research
Hormonal
Tirzepatide increases the likelihood of achieving clinically meaningful weight loss thresholds (≥5%, ≥10%, ≥15%) in a dose-dependent manner, with 15 mg showing the highest odds ratios for all thresholds.
Higher doses of tirzepatide significantly increase your chances of losing 5%, 10%, or 15% of your body weight. The 15 mg dose offers the highest probability of achieving these milestones compared to lower doses.
StrongSupportsVERY_HIGH confidence
Tirzepatide also markedly increased the odds of achieving clinically meaningful weight loss: ≥ 5% (OR=11.32; p < 0.0001), ≥ 10% (OR=14.77; p < 0.0001), and ≥ 15% (OR=18.07; p < 0.0001).
Why this rating
Based on the same robust meta-analysis of 11 RCTs.
Source
Efficacy and safety of tirzepatide for weight loss in patients with obesity or type 2 diabetes: a systematic review and meta-analysis
Qiru Tian et al. · Frontiers in Endocrinology · 2025
Meta-analysis · 11 studiesCited 9×
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