Hormonal
Low-volume high-intensity interval training (LV-HIT) significantly reduces circulating miRNA-27b expression in women with polycystic ovary syndrome (PCOS), whereas high-volume HIT (HV-HIT) does not, despite both improving cardiorespiratory fitness.
For women with PCOS, low-volume high-intensity interval training (10 one-minute maximal efforts with rest) is effective at reducing circulating miRNA-27b levels, a marker linked to metabolism and inflammation. Interestingly, a higher-volume protocol (4x4 minutes) improved fitness but did not change this specific marker, suggesting that training volume and structure matter for molecular adaptations even when fitness gains are similar.
In LV-HIT, but not HV-HIT, the expression of c-miR-27b decreased (0.5-fold, P = 0.007)... Despite increased cardiorespiratory fitness, HV-HIT did not alter the expression of any circulating, gluteal or abdominal AT miRNAs.
Why this rating
Randomized controlled trial with clear grouping, though the sample size for the specific molecular analysis (n=13 for LV-HIT) is modest.
Source
Circulating and Adipose Tissue miRNAs in Women With Polycystic Ovary Syndrome and Responses to High-Intensity Interval Training
Sofie Lionett et al. · Frontiers in Physiology · 2020
DOI 10.3389/fphys.2020.00904
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