Adherence

Tirzepatide significantly reduces ad libitum energy intake and body weight in adults with overweight or obesity, primarily by decreasing fasting appetite, food cravings, and disinhibition rather than increasing cognitive restraint.

Tirzepatide, a once-weekly injectable medication, significantly reduces food intake and body weight in adults with overweight or obesity. It works by lowering appetite, reducing food cravings, and decreasing the tendency to overeat, rather than by increasing willpower or cognitive restraint. While gastrointestinal side effects like nausea are common, they are often mild and tend to occur more frequently after the first injection. This suggests that tirzepatide can be an effective tool for managing energy intake and promoting weight loss, particularly for those who struggle with appetite and cravings.