Research
Adherence
Initiating anti-obesity medications (AOMs) at the weight loss plateau (WLP) is more effective for achieving additional weight loss than waiting until significant weight regain occurs.
Do not wait for significant weight regain to seek help. If your weight stops dropping after surgery (plateau), discuss starting an anti-obesity medication immediately to maximize your results.
ModerateSupportsMEDIUM confidence
Several studies have suggested that greater weight loss was achieved when AOMs were initiated at the weight loss plateau rather than waiting for weight regain (17, 19, 40), with one study demonstrating statistical significance (20).
Why this rating
Based on retrospective studies and one study with statistical significance.
Source
Pharmacologic management of weight regain following bariatric surgery
Eugene Lucas et al. · Frontiers in Endocrinology · 2023
DOI 10.3389/fendo.2022.1043595
narrative_reviewCited 31×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Pharmacologic management using GLP-1 receptor agonists (specifically liraglutide), topiramate, and phentermine/topiramate is effective for treating weight regain or weight loss plateaus following bariatric surgery.Moderate
- Newer GLP-1/GIP receptor agonists (semaglutide, tirzepatide) are expected to provide superior post-operative weight loss compared to prior GLP-1 RAs, despite a lack of specific post-surgical clinical trials.Limited
Related findings · Adherence
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- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →