Hormonal
A higher polygenic score for BMI is associated with lower weight loss following bariatric surgery, although the effect size is modest and attenuates in sensitivity analyses.
If you are considering bariatric surgery, having a high genetic risk for obesity might mean you lose slightly less weight than someone with low genetic risk. However, the surgery is still very effective. You may need to be more vigilant with lifestyle changes or consider adjunct therapies like GLP-1 RAs to maintain your results.
A higher body mass index polygenic score was modestly linked to lower weight loss after BS (+0.7% per s.d., P = 1.24 × 10−4), but the effect attenuated in sensitivity analyses.
Why this rating
Large study (n=4,210) but effect attenuates in sensitivity analyses and heterogeneity exists.
Source
Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery
J German et al. · Nature Medicine · 2025
DOI 10.1038/s41591-025-03645-3
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