Hormonal
Liraglutide (3.0 mg daily) is effective for weight loss but significantly less so than Semaglutide, with a mean weight loss of 6.4% compared to 15.8%.
Liraglutide (3.0 mg daily) is an FDA-approved option for weight loss, but it produces roughly half the weight loss of Semaglutide (6.4% vs 15.8%). It requires daily injections, which may be burdensome, and you must reach the 3.0 mg dose to see full effects. If you cannot tolerate Semaglutide, this is a viable alternative, but expect less dramatic results.
Results demonstrated that semaglutide resulted in significantly greater weight loss compared to liraglutide, with a mean weight reduction of 15.8% vs. 6.4%, respectively
Why this rating
Supported by STEP 8 trial (p<0.001).
Source
Comparative Effectiveness of Semaglutide, Liraglutide, Orlistat, and Phentermine for Weight Loss in Obese Individuals: A Systematic Review
Jay Prakash Patel et al. · Cureus · 2025
DOI 10.7759/cureus.80321
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