Research
Hormonal
Semaglutide had substantial effects on multiple secondary alcohol-related and somatic outcomes.
Semaglutide may improve various aspects of health related to alcohol use disorder in addition to reducing drinking.
StrongSupportsmedium confidence
Semaglutide...had substantial effects on multiple secondary alcohol-related and somatic outcomes.
Why this rating
Based on the randomized, double-blind, placebo-controlled trial design.
Source
Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial
Mette Kruse Klausen et al. · The Lancet · 2026
DOI 10.1016/s0140-6736(26)00305-3
rct · n=108Cited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Semaglutide was associated with a reduction in heavy drinking days by -41.1 percentage points from baseline compared to placebo, which had a reduction of -26.4 percentage points.Strong
- Adverse events from semaglutide were generally mild to moderate gastrointestinal effects and occurred more frequently in the semaglutide group.Strong
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- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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