Research
Energy balance
Emerging evidence suggests that combining IF and KD may offer synergistic metabolic effects.
Practitioners may explore the combination of IF and KD for enhanced metabolic benefits in patients.
GoodQualifiesmedium confidence
Emerging evidence suggests that combining IF and KD may offer synergistic metabolic effects.
Why this rating
The claim is based on emerging evidence, which is less robust than established findings.
Source
The role of intermittent fasting and ketogenic diet in metabolic syndrome and type 2 diabetes
Charlotte Delrue et al. · Acta Clinica Belgica · 2025
DOI 10.1080/17843286.2025.2540287
reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Both intermittent fasting (IF) and ketogenic diet (KD) independently show clinically significant benefits in improving metabolic parameters in metabolic syndrome (MetS) and type 2 diabetes (T2D), including reductions in HbA1c, fasting glucose, body weight, and triglycerides.Strong
- Both IF and KD enhance insulin sensitivity, promote autophagy, reduce inflammation, and activate energy-regulating pathways (AMPK) while inhibiting mTOR.Strong
Related findings · Energy balance
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- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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