Research
Energy balance
Cardiovascular autonomic neuropathy (CAN) is not significantly associated with mortality in men with type 2 diabetes.
Men with type 2 diabetes may require different monitoring strategies for mortality risk compared to women.
StrongRefutesmedium confidence
CAN was not significantly associated with mortality in men.
Why this rating
The study is based on a large RCT (ACCORD trial).
Source
Sex Differences in the Association Between Cardiovascular Autonomic Neuropathy and Mortality in Patients With Type 2 Diabetes: The ACCORD Study
Ziwei Zhou et al. · Journal of the American Heart Association · 2025
DOI 10.1161/jaha.124.034626
cohort · n=7866Cited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- In women with type 2 diabetes, cardiovascular autonomic neuropathy (CAN) is significantly associated with an increased risk of all-cause mortality (CAN1: HR 1.64, CAN2: HR 1.58, CAN3: HR 1.78) and cardiovascular disease mortality (CAN1: HR 2.25, CAN2: HR 2.22, CAN3: HR 3.31).Strong
- There is a significant multiplicative interaction of cardiovascular autonomic neuropathy (CAN) and sex on both mortality outcomes.Strong
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