Research
Hormonal
1 kg/m² lower BMI via the GIP/GIPR score is associated with 43% lower risk of heart failure.
Targeting GIP receptor pathways may significantly reduce heart failure risk.
StrongSupportsmedium confidence
In one-sample MR analyses, 1 kg/m² lower BMI via the GIP/GIPR score was associated with 43% lower risk of heart failure (P = 5 × 10⁻⁵).
Why this rating
Based on large sample size and Mendelian randomization analysis.
Source
Genetic variants of glucose-dependent insulinotropic polypeptide (GIP) signalling as proxy for body weight reduction and cardiovascular risk
Frida Emanuelsson et al. · European Heart Journal · 2025
other · n=408056Cited 3×
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