Research
Metabolic adaptation
Genetic proxies for body weight reduction via GIP receptor targeting reduces the risk of MACE and heart failure, mediated partly through lower BMI and partly through lower HbA1c.
Understanding GIP receptor pathways can inform strategies for reducing cardiovascular risks.
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Genetic proxies for body weight reduction via GIP receptor targeting reduces the risk of MACE and heart failure, mediated partly through lower BMI and partly through lower HbA1c.
Why this rating
Based on large sample size and Mendelian randomization analysis.
Source
Genetic variants of glucose-dependent insulinotropic polypeptide (GIP) signalling as proxy for body weight reduction and cardiovascular risk
Frida Emanuelsson et al. · European Heart Journal · 2025
other · n=408056Cited 3×
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