Research
Molecular
GPR75 and its ligand promote hypertension, inflammation, obesity, and insulin resistance.
Understanding the role of GPR75 can inform strategies to mitigate obesity-related health risks.
StrongSupportsmedium confidence
GPR75 and its association with its ligand, 20-hydroxyeicosatetraenoic acid, have been shown to promote hypertension, inflammation, obesity, and insulin resistance.
Why this rating
The claim is based on established associations discussed in the review.
Source
GPR75: A Newly Identified Receptor for Targeted Intervention in the Treatment of Obesity and Metabolic Syndrome
Michael Fragner et al. · Cardiology in Review · 2024
reviewCited 3×
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