Research
Molecular
The Low-Fat Plus diet resulted in a greater reduction in total cholesterol compared to the Low-Fat diet, with changes of -0.46 mmol/L (-17.6 mg/dL) versus -0.24 mmol/L (-9.2 mg/dL) respectively (P = 0.01).
Practitioners should consider recommending a plant-based diet to enhance cholesterol-lowering effects in hypercholesterolemic patients.
StrongSupportsmedium confidence
Four-week changes in the Low-Fat and Low-Fat Plus groups were -0.24 mmol/L (-9.2 mg/dL) versus -0.46 mmol/L (-17.6 mg/dL) for total cholesterol (P = 0.01).
Why this rating
Based on the randomized clinical trial design.
Source
The Effect of a Plant-Based Diet on Plasma Lipids in Hypercholesterolemic Adults
Christopher D. Gardner et al. · Annals of Internal Medicine · 2005
DOI 10.7326/0003-4819-142-9-200505030-00007
rct · n=120Cited 118×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The Low-Fat Plus diet led to a greater reduction in LDL cholesterol compared to the Low-Fat diet, with changes of -0.36 mmol/L (-13.8 mg/dL) versus -0.18 mmol/L (-7.0 mg/dL) respectively (P = 0.02).Strong
- The two diet groups did not differ significantly in high-density lipoprotein cholesterol and triglyceride levels.Strong
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