Research
Hormonal
Adding semaglutide to usual care in US adults without diabetes is projected to avert 358,400 major adverse cardiovascular events (MACE) at a cost of $148,100 per quality-adjusted life-year (QALY) gained.
Semaglutide may be a beneficial addition to treatment plans for eligible patients to reduce cardiovascular risks.
StrongSupportsmedium confidence
Adding semaglutide to usual care in the estimated 4 million US adults without diabetes eligible for secondary prevention of CVD is projected to avert 358 400 MACE at a cost of $148 100 per QALY gained.
Why this rating
Based on a population-based cohort simulation study design.
Source
Cost-Effectiveness of Semaglutide for Secondary Prevention of Cardiovascular Disease in US Adults
Susan Hennessy et al. · JAMA Cardiology · 2026
DOI 10.1001/jamacardio.2025.5243
cohort · n=4000000Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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