Hormonal
GLP-1 receptor agonists (e.g., Liraglutide) and SGLT2 inhibitors (e.g., Empagliflozin) reduce cardiovascular mortality in Type 2 Diabetes patients, primarily through mechanisms involving insulin sensitivity and weight loss rather than direct glucose lowering.
If you have Type 2 Diabetes and are at high risk for heart problems, medications like Liraglutide (a GLP-1 agonist) or Empagliflozin (an SGLT2 inhibitor) can significantly reduce your risk of dying from cardiovascular causes. These drugs work not just by lowering blood sugar, but by improving how your body uses insulin and promoting weight loss. Discuss these options with your doctor, especially if you have existing heart disease.
Recent clinical trials about the cardiovascular safety of empagliflozin and liraglutide demonstrated a convincing lowering effect on mortality from cardiovascular causes among the patients with type 2 diabetes. ... It is important to note that the glucose-lowering effect was moderate, although a feature seen in both empagliflozin and liraglutide was their ability to increase insulin sensitivity.
Why this rating
Based on large, landmark randomized clinical trials (LEADER, EMPA-REG OUTCOME).
Source
Decrease of cardiovascular risk in patients with type 2 diabetes: review of the common strategies and clinical studies
В. В. Салухов et al. · Diabetes Mellitus · 2018
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