Adherence
Intensive lifestyle modification (diet and exercise) reduces cardiovascular risk in Type 2 Diabetes patients, but long-term maintenance of weight loss is difficult, and significant risk reduction is only seen in those who maintain >10% weight loss.
Losing weight through diet and exercise is one of the best things you can do for your heart if you have Type 2 Diabetes. However, it is hard to keep the weight off. If you can lose and keep off more than 10% of your body weight, your risk of heart problems drops significantly. Even if you can't maintain that much weight loss, any improvement in your diet and activity level is beneficial. Don't be discouraged if you regain some weight; focus on making sustainable changes.
The Look AHEAD study ... was stopped after 11.5 years due to the absence of any significant reduction in the frequency of the primary endpoint. ... post-hoc analysis showed that among patients who achieved and maintained weight loss of more than 10%, the frequency of adverse cardiovascular outcomes was significantly reduced by 21%.
Why this rating
Based on the large, rigorous Look AHEAD trial, though the primary endpoint was not met, a significant post-hoc finding was reported.
Source
Decrease of cardiovascular risk in patients with type 2 diabetes: review of the common strategies and clinical studies
В. В. Салухов et al. · Diabetes Mellitus · 2018
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