Adherence
Intensive lifestyle modification (diet and exercise) reduces cardiovascular risk in Type 2 Diabetes patients, but long-term maintenance of weight loss is difficult, and significant risk reduction is only seen in those who maintain >10% weight loss.
Losing weight through diet and exercise is one of the best things you can do for your heart if you have Type 2 Diabetes. However, it is hard to keep the weight off. If you can lose and keep off more than 10% of your body weight, your risk of heart problems drops significantly. Even if you can't maintain that much weight loss, any improvement in your diet and activity level is beneficial. Don't be discouraged if you regain some weight; focus on making sustainable changes.
The Look AHEAD study ... was stopped after 11.5 years due to the absence of any significant reduction in the frequency of the primary endpoint. ... post-hoc analysis showed that among patients who achieved and maintained weight loss of more than 10%, the frequency of adverse cardiovascular outcomes was significantly reduced by 21%.
Why this rating
Based on the large, rigorous Look AHEAD trial, though the primary endpoint was not met, a significant post-hoc finding was reported.
Source
Decrease of cardiovascular risk in patients with type 2 diabetes: review of the common strategies and clinical studies
В. В. Салухов et al. · Diabetes Mellitus · 2018
DOI 10.14341/dm9570
More from this paper
- Thiazolidinediones (specifically Pioglitazone) significantly reduce cardiovascular events (stroke, MI, mortality) in patients with Type 2 Diabetes and macroangiopathies or recent stroke/TIA, independent of glucose lowering.Strong
- GLP-1 receptor agonists (e.g., Liraglutide) and SGLT2 inhibitors (e.g., Empagliflozin) reduce cardiovascular mortality in Type 2 Diabetes patients, primarily through mechanisms involving insulin sensitivity and weight loss rather than direct glucose lowering.Strong
- Reducing insulin resistance, rather than strictly lowering blood glucose, is the primary mechanism for reducing cardiovascular risk in type 2 diabetes.Good
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
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