Research
Hormonal
There was a 20% increase in hormone sensitive lipase (HSL) activity after the FAT-adpt diet compared to the high-CHO diet.
An increase in HSL may suggest enhanced fat mobilization, but the lack of significance warrants caution in application.
StrongQualifiesmedium confidence
There was a ∼20% increase (p=0.116) in HSL after the FAT-adpt compared to CHO during rest and cycling.
Why this rating
Based on study design from abstract.
Source
Decreased Skeletal Muscle Pyruvate Dehydrogenase Activation During Cycling Following Short-term High-fat Adaptation With Carbohydrate Restoration
Trent Stellingwerff et al. · Medicine & Science in Sports & Exercise · 2005
DOI 10.1097/00005768-200505001-00056
other · n=7Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A 5-day high-fat diet followed by 1-day carbohydrate restoration resulted in a 45% increase in fat oxidation and a 30% decrease in carbohydrate oxidation during cycling at 70% VO2 peak.Strong
- Skeletal muscle pyruvate dehydrogenase activation (PDHa) was 29% lower during the FAT-adpt diet compared to the high-CHO diet.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →