Research
Molecular
GLP-1 RAs slow both thoracic and abdominal aneurysm growth.
GLP-1 RAs may be beneficial in managing aneurysms in clinical settings.
StrongSupportsmedium confidence
In vitro and rodent studies show that GLP-1 RAs inhibit IL-1β, TNF-α, and matrix metalloproteinases, preserving elastin structure, and promoting M2 macrophage activity, slowing both thoracic and abdominal aneurysm growth.
Why this rating
Supported by in vitro and rodent studies.
Source
Beyond Glycemic Control: Glucagon-Like Peptide-1 Receptor Agonists as Potential Modifiers of Aortic Disease
Kanwardeep Singh et al. · Cardiology in Review · 2025
reviewCited 2×
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