Research
Hormonal
Semaglutide therapy leads to a higher percentage weight loss of 12.61% ± 4.11% compared to 4.84% ± 5.18% in controls from 6 to 12 months post LSG (p < 0.0001).
Semaglutide may be recommended for patients post-surgery to enhance weight loss outcomes.
StrongSupportsmedium confidence
From 6 to 12 months, the treatment group experienced significantly greater percentage (12.61% ± 4.11% vs. 4.84% ± 5.18%; p < 0.0001) weight loss than controls.
Why this rating
The study design is a retrospective analysis with matched controls, indicating strong evidence.
Source
Short‐Term Weight Loss Outcomes of 1.0 <scp>mg</scp> Semaglutide Therapy Initiated 6 Months After Sleeve Gastrectomy
Min He et al. · Obesity · 2025
DOI 10.1002/oby.70006
cohort · n=136Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Semaglutide initiated 6 months post LSG results in significantly greater absolute weight loss of 14.03 ± 5.26 kg compared to 5.63 ± 6.25 kg in controls from 6 to 12 months post LSG (p < 0.0001).Strong
- At 12 months, total weight loss was higher in the treatment group (35.77% ± 8.35%) compared to controls (28.37% ± 7.41%; p < 0.0001).Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →