Hormonal

GLP-1 receptor agonists produced greater weight loss among women (10.9%; 95% CI, 7.0%-14.8%) than men (6.8%; 95% CI, 4.6%-9.0%).

Practitioners should consider gender differences when prescribing GLP-1 receptor agonists for weight loss.

StrongSupportsmedium confidence

Among 6 trials (19 906 patients) analyzed by sex, weight loss was greater among women (10.9%; 95% CI, 7.0%-14.8%) than men (6.8%; 95% CI, 4.6%-9.0%).

G. Caleb Alexander et al. · JAMA Internal Medicine · 2026

Why this rating

Based on meta-analysis of multiple RCTs.

Source

Heterogeneity of Treatment Effects of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss in Adults

G. Caleb Alexander et al. · JAMA Internal Medicine · 2026

Meta-analysisCited 2×

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