Research
Molecular
The nanocomplexes showed markedly delayed release of semaglutide, with only 19% drug release over 7 days.
The delayed release may improve the effectiveness of semaglutide in clinical settings.
StrongSupportsmedium confidence
In contrast, the nanocomplexes showed markedly delayed release, with a concentration-dependent relationship between PS/Zn contents and SMG release rate, exhibiting 19% drug release over 7 days in the optimized formula.
Why this rating
Based on study design from abstract.
Source
Design of Electrostatic Nanocomplex of Semaglutide with Protamine and Zinc for Subcutaneous Prolonged Delivery
In Gyu Yang et al. · Nanomaterials · 2025
DOI 10.3390/nano15181399
otherCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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