Research
Energy balance
Gastrointestinal adverse effects are the most common safety concern associated with incretin analogs.
Clinicians should monitor for gastrointestinal side effects when prescribing incretin analogs.
GoodSupportsmedium confidence
Safety data were relatively similar across all trials and identified gastrointestinal adverse effects as most common.
Why this rating
Based on the review of safety data from multiple trials.
Source
Incretin Analogs for Weight Management in Adults Without Diabetes
Alison Lobkovich et al. · Annals of Pharmacotherapy · 2023
DOI 10.1177/10600280231190089
review · n=15Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Incretin analogs (liraglutide, semaglutide, and tirzepatide) are effective for weight management in adults without diabetes, with percent weight loss ranging from 5.7% to 20.9%.Strong
- Incretin analogs are preferred for overweight or obese patients according to the American Gastroenterological Association.Good
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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