Mixed
In adults with type 2 diabetes, unintentional or pharmacologically induced weight gain exceeding 5% over three years is associated with a reduced risk of incident cardiovascular disease and coronary heart disease, particularly in individuals over 60 years old.
For older adults with type 2 diabetes, aggressive weight loss strategies may not be the primary goal for cardiovascular protection. Instead, focusing on stable weight or allowing for modest, non-adipose weight gain (potentially from muscle or metabolic reserve) may be associated with better heart outcomes than intentional weight loss, particularly if the patient is on sulfonylureas. Consult a doctor before changing weight management goals.
Over 5% weight gain was associated with reduced risks of CVD and CHD development by the HRs of 0.70 [95% CI 0.48–1.01; P-value: 0.058] and 0.61 [0.40–0.93], respectively, in multivariable analysis.
Why this rating
Prospective cohort study with long follow-up (14.4 years) and multivariable adjustment, but observational design prevents causal inference.
Source
Weight change and risk of cardiovascular disease among adults with type 2 diabetes: more than 14 years of follow-up in the Tehran Lipid and Glucose Study
Seyyed Saeed Moazzeni et al. · Cardiovascular Diabetology · 2021
DOI 10.1186/s12933-021-01326-2
Related findings · Mixed
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