Research
Metabolic adaptation
Up to 33% of the weight lost on GLP-1 RAs may be lean tissue mass.
Practitioners should monitor body composition changes in patients using GLP-1 RAs.
StrongQualifiesmedium confidence
Up to 33% of the weight lost is lean tissue mass (muscle and bone).
Why this rating
The claim is based on specific data presented in the abstract.
Source
Navigating the benefits and harms of GLP-1 and GLP-1/GIP agonists in obesity
Raymond J. O’Connor · Drug and Therapeutics Bulletin · 2026
reviewCited 1×
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