Research
Mixed
High-volume resistance training increases non-myofibrillar protein synthesis rates more than high-load resistance training, suggesting a mechanism for sarcoplasmic hypertrophy.
High-volume training may promote muscle growth through increased non-myofibrillar protein synthesis, which contributes to sarcoplasmic hypertrophy. This suggests that volume-based protocols can drive muscle growth through mechanisms beyond just contractile protein accretion.
GoodSupportsHIGH confidence
Six-week integrated non-myofibrillar protein synthesis (iNon-MyoPS) rates were also higher in the HV versus HL condition, while no difference between conditions existed for iMyoPS rates.
Why this rating
Robust molecular analysis using tracer methods.
Source
Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
Christopher G. Vann et al. · Frontiers in Physiology · 2022
rct · n=15Cited 25×
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