Research
Mixed
High-volume resistance training increases non-myofibrillar protein synthesis rates more than high-load resistance training, suggesting a mechanism for sarcoplasmic hypertrophy.
High-volume training may promote muscle growth through increased non-myofibrillar protein synthesis, which contributes to sarcoplasmic hypertrophy. This suggests that volume-based protocols can drive muscle growth through mechanisms beyond just contractile protein accretion.
GoodSupportsHIGH confidence
Six-week integrated non-myofibrillar protein synthesis (iNon-MyoPS) rates were also higher in the HV versus HL condition, while no difference between conditions existed for iMyoPS rates.
Why this rating
Robust molecular analysis using tracer methods.
Source
Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
Christopher G. Vann et al. · Frontiers in Physiology · 2022
DOI 10.3389/fphys.2022.857555
rct · n=15Cited 25×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- High-volume resistance training (lighter loads, higher reps) produces greater skeletal muscle hypertrophy than high-load resistance training (heavier loads, fewer reps) when volume is equated or higher in the high-volume condition.Good
- High-load resistance training produces greater strength gains than high-volume resistance training, despite potentially lower hypertrophic outcomes in the short term.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →